Biochemical heterogeneity of Mycobacterium tuberculosis complex isolates in Guinea-Bissau.
نویسندگان
چکیده
Fifty-six strains of the Mycobacterium tuberculosis complex from patients in Guinea-Bissau were examined by using four biochemical tests (niacin production, nitrate reductase, pyrazinamidase, and resistance to thiophen-2-carboxylic acid hydrazide). The isolates were divided into five different biovars within a spectrum ranging from classical human M. tuberculosis to classical M. bovis.
منابع مشابه
The Guinea-Bissau Family of Mycobacterium tuberculosis Complex Revisited
The Guinea-Bissau family of strains is a unique group of the Mycobacterium tuberculosis complex that, although genotypically closely related, phenotypically demonstrates considerable heterogeneity. We have investigated 414 M. tuberculosis complex strains collected in Guinea-Bissau between 1989 and 2008 in order to further characterize the Guinea-Bissau family of strains. To determine the strain...
متن کاملEvolution and clonal traits of Mycobacterium tuberculosis complex in Guinea-Bissau.
Two hundred twenty-nine consecutive isolates of Mycobacterium tuberculosis complex from patients with pulmonary tuberculosis in Guinea-Bissau, which is located in West Africa, were analyzed for clonal origin by biochemical typing and DNA fingerprinting. By using four biochemical tests (resistance to thiophene-2-carboxylic acid hydrazide, niacin production, nitrate reductase test, and pyrazinami...
متن کاملIdentification of Mycobacterium Tuberculosis Complex, Using Molecular Methods
Abstract Background and Objective: A high level of homogeneity observed within all bacteria in the Mycobacterium tuberculosis complex makes a property that seriously challenges traditional biochemical-based identification methods of these pathogens in the laboratory. The work presented here was conducted to characterize Mycobacterium tuberculosis complex isolates in Golestan, Northern Iran. ...
متن کاملتشخیص سریع مایکوباکتریوم‌های آتیپیک در بیماران با علایم سل ریوی: ارزیابی لوکوس (QUB 3232 (590bp با روش VNTR
Background and Objective: Identification of atypical mycobacterium (Non tuberculosis Mycobacterium NTM) is important because of the worldwide propagation of these organisms. Recently, molecular studies have identified the specific loci for mycobacterium species by DNA - finger printing methods, but these methods are time-consuming and expensive. In this study, in addition to hsp65 PCR-RFLP meth...
متن کاملMolecular Epidemiology of Tuberculosis
Tuberculosis (TB) is a global epidemic, with one third of the world’s population infected, at least 9 million new active cases per year and about 2 million deaths per year. Without adequate chemotherapy treatment TB may be a mortal disease. In countries like Sweden the mortality was dramatically reduced about half a century ago when modern TB drugs where introduced. These gains are however seri...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Journal of clinical microbiology
دوره 31 8 شماره
صفحات -
تاریخ انتشار 1993